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chlorpromazine will decrease the extent or impact of codeine by influencing hepatic enzyme CYP2D6 metabolism. Use Caution/Keep track of. Stops conversion of codeine to its Energetic metabolite morphine
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amiodarone will improve the stage or impact of codeine by influencing hepatic enzyme CYP2D6 metabolism. Use Caution/Keep track of. Stops conversion of codeine to its Energetic metabolite morphine.
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Beginning on the 25mg dose may be proposed When you've got any possibility elements which cause you to far more susceptible to Unintended effects (like diabetic issues by way of example).
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Prevent use when having any oral drug that is dependent on threshold concentrations for efficacy. Interactions detailed are consultant illustrations and don't involve all possible clinical examples.